[HTML][HTML] Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

…, S Harguindey, SJ Reshkin, ME Ibrahim, C Rauch - Cancer cell …, 2015 - Springer
Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …

Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach

…, EP Spugnini, YG Assaraf, T Azzarito, C Rauch… - Drug Resistance …, 2015 - Elsevier
… the biophysical properties of the cellular membrane (Rauch and Pluen, 2007) and that,
these membrane alterations can be brought about by a change in cytosolic pH (Rauch, 2009b). …

Identification and characterization of a new member of the TNF family that induces apoptosis

…, JK Nicholl, GR Sutherland, TD Smith, C Rauch… - Immunity, 1995 - cell.com
… TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear
homology to other TNF family members. TRAIL transcripts are detected in a variety of human …

[HTML][HTML] Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs–an integral molecular/biochemical/metabolic/clinical …

…, JL Arranz, JD Polo Orozco, C Rauch… - Journal of translational …, 2013 - Springer
In recent years an increasing number of publications have emphasized the growing
importance of hydrogen ion dynamics in modern cancer research, from etiopathogenesis and …

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

RA Black, CT Rauch, CJ Kozlosky, JJ Peschon… - Nature, 1997 - nature.com
… I = I, „c”/(c" -- K",), where I is the current, I, is the maximal current, c is the cAMP concentration,
… 13) and c = 15 pM as the concentration of cAMP estimated to produce 90% of the maximal …

An essential role for ectodomain shedding in mammalian development

…, N Nelson, CJ Kozlosky, MF Wolfson, CT Rauch… - Science, 1998 - science.org
The ectodomains of numerous proteins are released from cells by proteolysis to yield
soluble intercellular regulators. The responsible protease, tumor necrosis factor-α converting …

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

…, T Le, C Smith, P Smolak, RG Goodwin, CT Rauch… - Nature medicine, 1999 - nature.com
… ligand family member) express the C–terminal ~150 amino acids, … c), which were
morphologically compatible with apoptotic necrosis (d, arrow). Scale bar represents 50 μm in a and c

Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor

…, C Rauch, S Srinivasan, V Fung, C Beers… - Science, 1994 - science.org
… Bone marrow of either female BALB/c or C57BLU6 mice was depleted of T cells with
monoclonal antibody (mAb) J1j (anti-Thy-1), mAb C3P0 (anti-CD2), mAb RL172 (anti-CD4), and …

[HTML][HTML] TRAIL‐R2: a novel apoptosis‐mediating receptor for TRAIL

…, CA Smith, RG Goodwin, CT Rauch - The EMBO …, 1997 - embopress.org
… ‐dimensional SDS–PAGE (B and C). Boxes 1 and 2 in (C) indicate the gel regions cut out …
4 min at 96C; 33 cycles, 1 min at 96C, 1 min at 46C, 2 min at 72C; and one cycle, 5 min at 72…

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

…, SD Lyman, A Baird, JM Wignall, J Eisenman, C Rauch… - Cell, 1990 - cell.com
We have previously reported the identification of a novel mast cell growth factor (MGF) that
was shown to be a ligand for c-kit and is encoded by a gene that maps near the steel locus on …