siRNAs can function as miRNAs
JG Doench, CP Petersen, PA Sharp - Genes & development, 2003 - genesdev.cshlp.org
With the discovery of RNA interference (RNAi) and related phenomena, new regulatory roles
attributed to RNA continue to emerge. Here we show, in mammalian tissue culture, that a …
attributed to RNA continue to emerge. Here we show, in mammalian tissue culture, that a …
[PDF][PDF] Short RNAs repress translation after initiation in mammalian cells
CP Petersen, ME Bordeleau, J Pelletier, PA Sharp - Molecular cell, 2006 - cell.com
MicroRNAs (miRNAs) are predicted to regulate 30% of mammalian protein-encoding genes
by interactions with their 3′ untranslated regions (UTRs). We use partially complementary …
by interactions with their 3′ untranslated regions (UTRs). We use partially complementary …
Mid-infrared supercontinuum covering the 1.4–13.3 μm molecular fingerprint region using ultra-high NA chalcogenide step-index fibre
The mid-infrared spectral region is of great technical and scientific interest because most
molecules display fundamental vibrational absorptions in this region, leaving distinctive …
molecules display fundamental vibrational absorptions in this region, leaving distinctive …
[HTML][HTML] Wnt signaling and the polarity of the primary body axis
CP Petersen, PW Reddien - Cell, 2009 - cell.com
How animals establish and pattern the primary body axis is one of the most fundamental
problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and …
problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and …
Gene silencing using micro-RNA designed hairpins
During RNA interference (RNAi), long dsRNA is processed to ∼21 nt duplexes, short
interfering RNAs (siRNAs), which silence genes through a mRNA degradation pathway. Small …
interfering RNAs (siRNAs), which silence genes through a mRNA degradation pathway. Small …
Smed-βcatenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration
CP Petersen, PW Reddien - Science, 2008 - science.org
Planarian flatworms can regenerate heads at anterior-facing wounds and tails at posterior-facing
wounds throughout the body. How this regeneration polarity is specified has been a …
wounds throughout the body. How this regeneration polarity is specified has been a …
14-3-3σ controls mitotic translation to facilitate cytokinesis
14-3-3 proteins are crucial in a wide variety of cellular responses including cell cycle
progression, DNA damage checkpoints and apoptosis. One particular 14-3-3 isoform, σ, is a p53-…
progression, DNA damage checkpoints and apoptosis. One particular 14-3-3 isoform, σ, is a p53-…
Polarized notum Activation at Wounds Inhibits Wnt Function to Promote Planarian Head Regeneration
CP Petersen, PW Reddien - Science, 2011 - science.org
Regeneration requires initiation of programs tailored to the identity of missing parts. Head-versus-tail
regeneration in planarians presents a paradigm for study of this phenomenon. After …
regeneration in planarians presents a paradigm for study of this phenomenon. After …
[HTML][HTML] Real-time high-resolution mid-infrared optical coherence tomography
The potential for improving the penetration depth of optical coherence tomography systems
by using light sources with longer wavelengths has been known since the inception of the …
by using light sources with longer wavelengths has been known since the inception of the …
A wound-induced Wnt expression program controls planarian regeneration polarity
CP Petersen, PW Reddien - Proceedings of the National …, 2009 - National Acad Sciences
Regeneration requires specification of the identity of new tissues to be made. Whether this
process relies only on intrinsic regulative properties of regenerating tissues or whether wound …
process relies only on intrinsic regulative properties of regenerating tissues or whether wound …