[BOOK][B] The competitive status of the UK automotive industry
M Holweg, P Davies, D Podpolny - 2009 - libralato.co.uk
The report was commissioned by the NAIGT Steering Group to provide an empirical basis of
the UK’s competitive status and the key challenges the industry faces. More specifically, the …
the UK’s competitive status and the key challenges the industry faces. More specifically, the …
[PDF][PDF] Capturing the new 'value'segment in medical devices
C Llewellyn, D Podpolny, C Zerbi - McKinsey & Company, January, 2015 - mckinsey.com
2 manufacturers have been looking to capture it and protect themselves from disrupters that
could eventually move upstream—for instance, Mindray in China. However, few have yet …
could eventually move upstream—for instance, Mindray in China. However, few have yet …
[PDF][PDF] Private equity opportunities in healthcare tech
…, A Davidson, J Littlejohns, D Podpolny - … and Company. May, 2019 - mckinsey.com
Healthcare technology companies have historically gotten less attention from private equity (PE)
investors than they might warrant. Admittedly, healthcare tech is complex, making it …
investors than they might warrant. Admittedly, healthcare tech is complex, making it …
European Healthcare: A Golden Opportunity for Private Equity
Y Erez, J Grigalauskas, D Podpolny… - The Journal of Private …, 2017 - JSTOR
Aging populations, the drive for better preventive medicines, and the increasing reliance on
the private sector to help societies pay for ballooning healthcare costs continue to make …
the private sector to help societies pay for ballooning healthcare costs continue to make …
[HTML][HTML] Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters
…, P Pascual-Vargas, S Benvegnù, M Podpolny… - Molecular …, 2022 - nature.com
Growing evidence supports a role for deficient Wnt signalling in Alzheimer’s disease (AD).
First, the Wnt antagonist DKK1 is elevated in AD brains and is required for amyloid-β-induced …
First, the Wnt antagonist DKK1 is elevated in AD brains and is required for amyloid-β-induced …
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
FA Aprile, P Sormanni, M Podpolny… - Proceedings of the …, 2020 - National Acad Sciences
… We first assessed the fitness of the worms for 10 d starting at 24 h of induction of aggregation
(Methods). We found that the GMC101 worms had the most dramatic drop of mobility …
(Methods). We found that the GMC101 worms had the most dramatic drop of mobility …
[PDF][PDF] Reversal of synapse degeneration by restoring Wnt signaling in the adult hippocampus
Synapse degeneration occurs early in neurodegenerative diseases and correlates strongly
with cognitive decline in Alzheimer's disease (AD). The molecular mechanisms that trigger …
with cognitive decline in Alzheimer's disease (AD). The molecular mechanisms that trigger …
Evaluation of synapse density in hippocampal rodent brain slices
F McLeod, A Marzo, M Podpolny, S Galli… - JoVE (Journal of …, 2017 - jove.com
In the brain, synapses are specialized junctions between neurons, determining the strength
and spread of neuronal signaling. The number of synapses is tightly regulated during …
and spread of neuronal signaling. The number of synapses is tightly regulated during …
Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model
N Martin-Flores, M Podpolny, F McLeod, I Workman… - bioRxiv, 2022 - biorxiv.org
Increasing evidence supports a role of deficient Wnt signaling in Alzheimer’s disease (AD).
Recent studies reveal that the secreted Wnt antagonist Dickkopf-3 (DKK3) is elevated in the …
Recent studies reveal that the secreted Wnt antagonist Dickkopf-3 (DKK3) is elevated in the …
Wnt7b signalling through Frizzled-7 receptor promotes dendrite development by coactivating CaMKII and JNK
…, ME Bernis, F McLeod, M Podpolny… - Journal of cell …, 2018 - journals.biologists.com
The formation of complex dendritic arbors is crucial for the assembly of functional networks
as abnormal dendrite formation underlies several neurodevelopmental and psychiatric …
as abnormal dendrite formation underlies several neurodevelopmental and psychiatric …