[BOOK][B] The competitive status of the UK automotive industry

M Holweg, P Davies, D Podpolny - 2009 - libralato.co.uk
The report was commissioned by the NAIGT Steering Group to provide an empirical basis of
the UK’s competitive status and the key challenges the industry faces. More specifically, the …

[PDF][PDF] Capturing the new 'value'segment in medical devices

C Llewellyn, D Podpolny, C Zerbi - McKinsey & Company, January, 2015 - mckinsey.com
2 manufacturers have been looking to capture it and protect themselves from disrupters that
could eventually move upstream—for instance, Mindray in China. However, few have yet …

[PDF][PDF] Private equity opportunities in healthcare tech

…, A Davidson, J Littlejohns, D Podpolny - … and Company. May, 2019 - mckinsey.com
Healthcare technology companies have historically gotten less attention from private equity (PE)
investors than they might warrant. Admittedly, healthcare tech is complex, making it …

European Healthcare: A Golden Opportunity for Private Equity

Y Erez, J Grigalauskas, D Podpolny… - The Journal of Private …, 2017 - JSTOR
Aging populations, the drive for better preventive medicines, and the increasing reliance on
the private sector to help societies pay for ballooning healthcare costs continue to make …

[HTML][HTML] Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters

…, P Pascual-Vargas, S Benvegnù, M Podpolny… - Molecular …, 2022 - nature.com
Growing evidence supports a role for deficient Wnt signalling in Alzheimer’s disease (AD).
First, the Wnt antagonist DKK1 is elevated in AD brains and is required for amyloid-β-induced …

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

FA Aprile, P Sormanni, M Podpolny… - Proceedings of the …, 2020 - National Acad Sciences
… We first assessed the fitness of the worms for 10 d starting at 24 h of induction of aggregation
(Methods). We found that the GMC101 worms had the most dramatic drop of mobility …

[PDF][PDF] Reversal of synapse degeneration by restoring Wnt signaling in the adult hippocampus

A Marzo, S Galli, D Lopes, F McLeod, M Podpolny… - Current Biology, 2016 - cell.com
Synapse degeneration occurs early in neurodegenerative diseases and correlates strongly
with cognitive decline in Alzheimer's disease (AD). The molecular mechanisms that trigger …

Evaluation of synapse density in hippocampal rodent brain slices

F McLeod, A Marzo, M Podpolny, S Galli… - JoVE (Journal of …, 2017 - jove.com
In the brain, synapses are specialized junctions between neurons, determining the strength
and spread of neuronal signaling. The number of synapses is tightly regulated during …

Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model

N Martin-Flores, M Podpolny, F McLeod, I Workman… - bioRxiv, 2022 - biorxiv.org
Increasing evidence supports a role of deficient Wnt signaling in Alzheimer’s disease (AD).
Recent studies reveal that the secreted Wnt antagonist Dickkopf-3 (DKK3) is elevated in the …

Wnt7b signalling through Frizzled-7 receptor promotes dendrite development by coactivating CaMKII and JNK

…, ME Bernis, F McLeod, M Podpolny… - Journal of cell …, 2018 - journals.biologists.com
The formation of complex dendritic arbors is crucial for the assembly of functional networks
as abnormal dendrite formation underlies several neurodevelopmental and psychiatric …