The Hedgehog (Hh) pathway plays critical roles in normal development and in tumorigenesis.
We generated Gli-luciferase transgenic mice to evaluate the Smo inhibitor, HhAntag, by …

Medulloblastoma is the most common malignant pediatric brain tumor. Current treatment is
associated with major long-term side effects; therefore, new nontoxic therapies, targeting …

During mammalian cell division, DNA methylation patterns are transferred accurately to the
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase activity…

Survivin is a member of the inhibitor of apoptosis protein (IAP) family containing a single
baculovirus IAP repeat domain. It is expressed during fetal development but becomes …

1As the demand for so-called eco-cars has been increasing recently, new hybrid transaxle
P610 has been developed to achieve outstanding fuel economy and an excellent driving …

Germline mutations in the human homolog of the patched1 (PTCH1) are associated with
basal cell nevus carcinoma syndrome (BCNS or Gorlin syndrome), which is characterized by …

Abnormal expression of Dnmt1 in vivo induces cellular alterations such as transformation, and
an increase in Dnmt1 mRNA plays a causal role in c‐fos‐, ras‐ and SV40 large T antigen‐…

The Sp family is a family of transcription factors that bind to cis‐elements in the promoter
regions of various genes. Regulation of transcription by Sp proteins is based on interactions …

How natural selection can promote cooperative or altruistic behavior is a fundamental
question in biological and social sciences. One of the persuasive mechanisms is "indirect …

Eukaryotic initiation factor 4A-3 (eIF4A3) is an Asp-Glu-Ala-Asp (DEAD) box-family adenosine
triphosphate (ATP)-dependent RNA helicase. Subtypes eIF4A1 and eIF4A2 are required …