The photoreceptor/RPE complex must maintain a delicate balance between maximizing the
absorption of photons for vision and retinal image quality while simultaneously minimizing …

Within the next decade, we will see many gene therapy clinical trials for eye diseases, which
may lead to treatments for thousands of visually impaired people around the world. To …

… Iwan Morgan's book provides a much-needed historical perspective on this perennially
troubling issue. The prominent role of Congress notwithstanding, Morgan closely examines the …

Twenty-five years ago, adaptive optics (AO) was combined with fundus photography, thereby
initiating a new era in the field of ophthalmic imaging. Since that time, clinical applications …

Background Gene therapy has the potential to reverse disease or prevent further deterioration
of vision in patients with incurable inherited retinal degeneration. We therefore did a …

This report examines the commercialization of gene therapy in the context of innovation
theories that posit a relationship between the maturation of a technology through its life cycle …

purpose. Retinal pigment epithelial (RPE) cells are critical for the health of the retina,
especially the photoreceptors. A recent study demonstrated that individual RPE cells could be …

purpose. Autofluorescence fundus imaging using an adaptive optics scanning laser
ophthalmoscope (AOSLO) allows for imaging of individual retinal pigment epithelial (RPE) cells in …

Purpose.: We characterized retinal structure in patients and carriers of choroideremia using
adaptive optics and other high resolution modalities. Methods.: A total of 57 patients and 18 …

Purpose To describe in detail the central retinal structure of a large group of patients with
choroideremia (CHM). Design A prospective, cross-sectional, descriptive study. Participants …