Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
…, H Bolouri, B Montgomery, T White, JM Lucas… - Nature medicine, 2016 - nature.com
Tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for
cancers that have metastasized. To determine whether the genomic alterations in a single …
cancers that have metastasized. To determine whether the genomic alterations in a single …
[PDF][PDF] Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans
Acute respiratory infections (ARIs) are a common reason for seeking medical attention, and
the threat of pandemic influenza will likely add to these numbers. Using human viral …
the threat of pandemic influenza will likely add to these numbers. Using human viral …
[HTML][HTML] Semi-automated assembly of high-quality diploid human reference genomes
The current human reference genome, GRCh38, represents over 20 years of effort to generate
a high-quality assembly, which has benefitted society 1 , 2 . However, it still has many …
a high-quality assembly, which has benefitted society 1 , 2 . However, it still has many …
Att3d: Amortized text-to-3d object synthesis
Text-to-3D modelling has seen exciting progress by combining generative text-to-image models
with image-to-3D methods like Neural Radiance Fields. DreamFusion recently achieved …
with image-to-3D methods like Neural Radiance Fields. DreamFusion recently achieved …
Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity
…, C Etienne, J Gibbons, J Grod, J Lucas… - Journal of medicinal …, 2001 - ACS Publications
Subsequent to the discovery of 4-[(2,4-dichlorophenyl)amino]-6,7-dimethoxy-3-quinolinecarbonitrile
(1a) as an inhibitor of Src kinase activity (IC 50 = 30 nM), several additional …
(1a) as an inhibitor of Src kinase activity (IC 50 = 30 nM), several additional …
JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles
…, L Turchi, R Blanc-Mathieu, J Lucas… - Nucleic acids …, 2022 - academic.oup.com
JASPAR ( http://jaspar.genereg.net/ ) is an open-access database containing manually
curated, non-redundant transcription factor (TF) binding profiles for TFs across six taxonomic …
curated, non-redundant transcription factor (TF) binding profiles for TFs across six taxonomic …
Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.
…, J Fuscoe, R Segraves, J Lucas… - Proceedings of the …, 1988 - National Acad Sciences
Chromosomes can be specifically stained in metaphase spreads and interphase nuclei by
in situ hybridization with entire chromosome-specific DNA libraries. Unlabeled human …
in situ hybridization with entire chromosome-specific DNA libraries. Unlabeled human …
Synthesis and SAR of [1,2,4]Triazolo[1,5-a]pyrimidines, a Class of Anticancer Agents with a Unique Mechanism of Tubulin Inhibition
…, J Afragola, R Hernandez, J Lucas… - Journal of medicinal …, 2007 - ACS Publications
The synthesis and SAR of a series of triazolopyrimidines as anticancer agents are described.
Treatment of 5-chloro-6-(trifluorophenyl)-N-fluoroalkyl [1,2,4]triazolo[1,5-a]pyrimidin-7-…
Treatment of 5-chloro-6-(trifluorophenyl)-N-fluoroalkyl [1,2,4]triazolo[1,5-a]pyrimidin-7-…
Exponentially weighted moving average control schemes: properties and enhancements
JM Lucas, MS Saccucci - Technometrics, 1990 - Taylor & Francis
… , we use a set of simulated observations taken from Lucas and Crosier (1982a). The data, …
We feel that it is convenient to have tables with fixed values of j. and in-control ARL’s. Table …
We feel that it is convenient to have tables with fixed values of j. and in-control ARL’s. Table …
[HTML][HTML] Role of tau protein in both physiological and pathological conditions
J Avila, JJ Lucas, MAR Perez… - Physiological …, 2004 - journals.physiology.org
… Pérez, JJ Lucas, and J. Avila, unpublished observations). Other tau isoforms that lack exon
2… However, the model generated by Lucas et al. (199) shows spatial learning deficits and …
2… However, the model generated by Lucas et al. (199) shows spatial learning deficits and …