Research in autophagy continues to accelerate, 1 and as a result many new scientists are
entering the field. Accordingly, it is important to establish a standard set of criteria for …

Protein folding in the endoplasmic reticulum (ER) is monitored by ER quality control (ERQC)
mechanisms. Proteins that pass ERQC criteria traffic to their final destinations through the …

More than 2000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR)
have been described that confer a range of molecular cell biological and functional …

Until recently, the degradation of aberrant and unassembled proteins retained in the
endoplasmic reticulum (ER) was thought to involve unidentified ER-localized proteases. We now …

To investigate the mechanisms of ER-associated protein degradation (ERAD), this process
was reconstituted in vitro. Established procedures for post-translational translocation of …

Protein folding is a complex, error-prone process that often results in an irreparable protein
by-product. These by-products can be recognized by cellular quality control machineries and …

Endoplasmic reticulum (ER)-associated degradation (ERAD) is the process by which
aberrant proteins in the ER lumen are exported back to the cytosol and degraded by the …

A variety of mutant polypeptides that are associated with human disease are targeted for
degradation by an endoplasmic reticulum (ER) quality control system. In addition, physiological …

All cellular proteins are subject to quality control "decisions," which help to prevent or delay a
myriad of diseases. Quality control within the secretory pathway creates a special challenge…

TDP-43 proteinopathy is a pathological hallmark of amyotrophic lateral sclerosis and
frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within degenerating …