Mechanism and clinical significance of wear debris-induced osteolysis

HC Amstutz, P Campbell, N Kossovsky… - … and Related Research …, 1992 - journals.lww.com
… Mouse pcritoneal Co 1 pm, Cr 5–30 pum Co, N, and CoCr alloy macrophage culture …
North Am. … N.: Macrophages stimulate bone resorption when they phagocytose particles. J. …

[PDF][PDF] Sterically stabilized liposomes. Reduction in electrophoretic mobility but not electrostatic surface potential

MC Woodle, LR Collins, E Sponsler, N Kossovsky… - Biophysical journal, 1992 - cell.com
The electrophoretic mobility of liposomes containing a negatively charged derivative of
phosphatidylethanolamine with a large headgroup composed of the hydrophilic polymer …

Surface-modified diamond nanoparticles as antigen delivery vehicles

N Kossovsky, A Gelman, HJ Hnatyszyn… - Bioconjugate …, 1995 - ACS Publications
… 1 One g of diamond powder (General Electric, Worthington OH) was cleaned by 400 W
sonication at 4 C in 12 N HC1 for 16 h and subsequently washed with ultrafiltered water until the …

Biocompatibility of silicone implants

JP Heggers, N Kossovsky, RW Parsons… - Annals of plastic …, 1983 - journals.lww.com
The biocompatibility of silicone implants has been a source of long-standing controversy. An
attempt to ascertain this biocompatibility with regard to the cellular immune mechanism was …

Cementless total joint arthroplasty prostheses with titanium-alloy articular surfaces: a human retrieval analysis

…, PA Campbell, D Kilgus, NIR Kossovsky… - Clinical Orthopaedics …, 1990 - journals.lww.com
Surgical implants of titanium alloy (Ti-6A1-4V) have been found to be susceptible to abrasive
wear, resulting in the well-known phenomenon of metallosis. In the presence of the acrylic …

Surface-modified nanocrystalline ceramics for drug delivery applications

N Kossovsky, A Gelman, EE Sponsler, HJ Hnatyszyn… - Biomaterials, 1994 - Elsevier
… Crystalline cyanoalkanes n-Alkane crystals Urea inclusion complexes Conformational stability
Kossovsky N, Millett D. Materials biotechnology and blood substitutes. MaterRes Sot Bull …

Control of molecular polymorphisms by a structured carbohydrate/ceramic delivery vehicle—aquasomes

N Kossovsky, A Gelman, S Rajguru, R Nguyen… - Journal of controlled …, 1996 - Elsevier
Molecular denaturation of polypeptides and other macromolecular pharmaceuticals upon
surface adsorption from an aqueous environment is almost inevitable. Molecular denaturation, …

Experimental demonstration of the immunogenicity of silicone–protein complexes

N Kossovsky, JP Heggers… - Journal of biomedical …, 1987 - Wiley Online Library
Although silicones, as a class, are nontoxic in animal and tissue studies, implanted silicone
prostheses and medical devices are associated with various local and systemic host …

Animal model of porous polyethylene orbital implants

…, SC Dresner, RA Braslow, N Kossovsky… - Ophthalmic Plastic & …, 1994 - journals.lww.com
Ophthalmologists continue to search for the ideal orbital implant for the anophthalmic socket.
The successful long-term clinical performance of an implantable prosthesis is highly …

Silicone breast implant pathology. Clinical data and immunologic consequences.

N Kossovsky, CJ Freiman - Archives of pathology & laboratory …, 1994 - europepmc.org
Silicone breast prostheses are medical devices, implanted subcutaneously or subpectorally,
that are designed to replace or augment the volume occupied by breast glandular tissue. …