Loosening of joint replacement components is often multifactorial. The quality of initial fixation
is very important to the outcome of the arthroplasty and is often a factor in short-term and …

Recognition of antigens by immunocompetent cells involves interactions that are specific to
the chemical sequence and conformation of the epitope (antigenic determinant). Adjuvants …

The biocompatibility of silicone implants has been a source of long-standing controversy. An
attempt to ascertain this biocompatibility with regard to the cellular immune mechanism was …

Surgical implants of titanium alloy (Ti-6A1-4V) have been found to be susceptible to abrasive
wear, resulting in the well-known phenomenon of metallosis. In the presence of the acrylic …

Drug delivery systems comprised of various types of carriers have long been the object of
pharmacological investigation. The search has been stimulated by the belief that carriers will …

Although silicones, as a class, are nontoxic in animal and tissue studies, implanted silicone
prostheses and medical devices are associated with various local and systemic host …

Ophthalmologists continue to search for the ideal orbital implant for the anophthalmic socket.
The successful long-term clinical performance of an implantable prosthesis is highly …

Silicone breast prostheses are medical devices, implanted subcutaneously or subpectorally,
that are designed to replace or augment the volume occupied by breast glandular tissue. …

Parenteral drug delivery systems have the potential to make drugs both safer and more
effective. While research in this field has been active for over 30 years, the current fiscal …

Infection and obstruction remain significant problems associated with shunts. We studied
the clinical and pathological findings in 29 patients who underwent surgical procedures to …