The seeding of an expanse of surface waters in the equatorial Pacific Ocean with low
concentrations of dissolved iron triggered a massive phytoplankton bloom which consumed large …

Inappropriate antibiotic use for pulmonary infiltrates is common in the intensive care unit (ICU).
We sought to devise an approach that would minimize unnecessary antibiotic use, …

It is important to understand which molecules are essential for long-lived immunity. We show
that OX40 (CD134) is required with CD28 for the survival of CD4 T cells following antigen-…

The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates
the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA …

BACKGROUND: To our knowledge, 17-allylamino,17-demethoxygeldanamycin (17AAG) is
the first inhibitor of heat shock protein 90 (Hsp90) to enter a phase I clinical trial in cancer. …

Purpose Anthracycline-induced cardiotoxicity (ACT) is a serious adverse drug reaction limiting
anthracycline use and causing substantial morbidity and mortality. Our aim was to identify …

T helper cell (Th) 1, but not Th2, effectors undergo rapid Fas/Fas ligand (FasL)-mediated,
activation-induced cell death upon restimulation with antigen. Unequal apoptosis is also …

The generation of memory T cells is critically important for rapid clearance and neutralization
of pathogens encountered previously by the immune system. We have studied the kinetics …

Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These
cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the …

Cisplatin is a widely used and effective chemotherapeutic agent, although its use is restricted
by the high incidence of irreversible ototoxicity associated with it 1 . In children, cisplatin …