Cystic fibrosis is the most common, lethal, genetic defect of white populations (1). Once limited
largely to infants and children, the immediate prognosis has changed drastically over the …

Type I collagen, the most abundant protein of the body, is preferentially synthesized in bone,
dermis, and tendons by two cell types, the osteoblast and the fibroblast. The expression of …

Background Surgical resection alone is regarded as the standard of care for patients with liver
metastases from colorectal cancer, but relapse is common. We assessed the combination …

Liver metastases are commonly detected in a range of malignancies including colorectal
cancer (CRC), pancreatic cancer, melanoma, lung cancer and breast cancer, although CRC is …

Chromatin is composed of DNA and a variety of modified histones and non-histone proteins,
which have an impact on cell differentiation, gene regulation and other key cellular …

The vision of creating accessible, reliable clinical evidence by accessing the clinical
experience of hundreds of millions of patients across the globe is a reality. The Observational …

To prepare a water-insoluble camptothecin (CPT) delivery carrier, hydrophobically modified
glycol chitosan (HGC) nanoparticles were constructed by chemical conjugation of …

Rapid phagocytic clearance of apoptotic cells is crucial for the prevention of both inflammation
and autoimmune responses. Phosphatidylserine (PS) at the external surface of the …

To make a tumor targeting nano-sized drug delivery system, biocompatible and biodegradable
glycol chitosan (M w =250 kDa) was modified with hydrophobic cholanic acid. The …

Theragnostic multifunctional nanoparticles hold great promise in simultaneous diagnosis of
disease, targeted drug delivery with minimal toxicity, and monitoring of treatment. One of the …