Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase
…, HJ Park, Y Tan, T Ackerson, RH Costa - … and cellular biology, 2005 - Taylor & Francis
The Forkhead box m1 (Foxm1) gene is critical for G 1 /S transition and essential for mitotic
progression. However, the transcriptional mechanisms downstream of FoxM1 that control …
progression. However, the transcriptional mechanisms downstream of FoxM1 that control …
Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and α1-antitrypsin genes
RH Costa, DR Grayson… - Molecular and cellular …, 1989 - Am Soc Microbiol
Transthyretin (TTR) and α1-antitrypsin (α1-AT) are expressed at high levels in the liver and
also in at least one other cell type. We report here a detailed analysis of the proximal …
also in at least one other cell type. We report here a detailed analysis of the proximal …
Transcription factors in liver development, differentiation, and regeneration
RH Costa, VV Kalinichenko, AXL Holterman… - Hepatology, 2003 - journals.lww.com
Transcriptional Activation. The liver performs essential functions in the body by uniquely
expressing hepatocyte-specific genes encoding plasma proteins, clotting factors and enzymes …
expressing hepatocyte-specific genes encoding plasma proteins, clotting factors and enzymes …
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.
…, VR Prezioso, E Smith, O Litvin, RH Costa… - Genes & …, 1990 - genesdev.cshlp.org
Hepatocyte-specific gene expression requires the interaction of many proteins with multiple
binding sites in the regulatory regions. HNF-3 is a site found to be important in the maximal …
binding sites in the regulatory regions. HNF-3 is a site found to be important in the maximal …
Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor
…, A Datta, P Raychaudhuri, RH Costa - Genes & …, 2004 - genesdev.cshlp.org
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide.
Here, we provide evidence that the Forkhead Box (Fox) m1b (Foxm1b or Foxm1) transcription …
Here, we provide evidence that the Forkhead Box (Fox) m1b (Foxm1b or Foxm1) transcription …
Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues
…, DG Overdier, KA Roebuck, RH Costa - … and cellular biology, 1997 - Am Soc Microbiol
The hepatocyte nuclear factor 3α (HNF-3α) and 3β proteins have homology in the winged
helix/fork head DNA binding domain and regulate cell-specific transcription in hepatocytes …
helix/fork head DNA binding domain and regulate cell-specific transcription in hepatocytes …
The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer
…, ML Major, GA Gusarova, HM Yoder, RH Costa… - Cancer research, 2006 - AACR
The proliferation-specific Forkhead Box m1 (Foxm1 or Foxm1b) transcription factor (previously
called HFH-11B, Trident, Win, or MPP2) regulates expression of cell cycle genes …
called HFH-11B, Trident, Win, or MPP2) regulates expression of cell cycle genes …
The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration
…, MB Dennewitz, RH Costa - Proceedings of the …, 2002 - National Acad Sciences
The Forkhead Box (Fox) proteins are an extensive family of transcription factors that shares
homology in the winged helix DNA-binding domain and whose members play essential roles …
homology in the winged helix DNA-binding domain and whose members play essential roles …
Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice
…, CJ Detrisac, VV Kalinichenko, A Lyubimov, RH Costa - Cancer research, 2006 - AACR
The proliferation-specific Forkhead Box M1 (FoxM1 or FoxM1b) transcription factor is
overexpressed in a number of aggressive human carcinomas. Mouse hepatocytes deficient in …
overexpressed in a number of aggressive human carcinomas. Mouse hepatocytes deficient in …
The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix
DG Overdier, A Porcella, RH Costa - Molecular and cellular …, 1994 - Am Soc Microbiol
Three distinct hepatocyte nuclear factor 3 (HNF-3) proteins (HNF-3α,-3β, and-3γ) are known
to regulate the transcription of liver-specific genes. The HNF-3 proteins bind to DNA as a …
to regulate the transcription of liver-specific genes. The HNF-3 proteins bind to DNA as a …