Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …

The classical pathway of interferon-γ-dependent activation of macrophages by T helper 1 (T
H 1)-type responses is a well-established feature of cellular immunity to infection with …

Heterogeneity of the macrophage lineage has long been recognized and, in part, is a result
of the specialization of tissue macrophages in particular microenvironments. Circulating …

As a result of an error during film output, Table 1 was published with some symbols missing.
The correct version can be found at http://www. sanger. ac. uk and is reproduced again here …

Description of macrophage activation is currently contentious and confusing. Like the biblical
Tower of Babel, macrophage activation encompasses a panoply of descriptors used in …

ContextDelirium is a common problem in the intensive care unit (ICU). Accurate diagnosis is
limited by the difficulty of communicating with mechanically ventilated patients and by lack …

ContextIn the intensive care unit (ICU), delirium is a common yet underdiagnosed form of
organ dysfunction, and its contribution to patient outcomes is unclear.ObjectiveTo determine if …

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

Background Only 15 to 20 percent of patients with chronic hepatitis C have a sustained
virologic response to interferon therapy. We compared the efficacy and safety of recombinant …

Background A sustained virological response (SVR) rate of 41% has been achieved with
interferon alfa-2b plus ribavirin therapy of chronic hepatitis C. In this randomised trial, …