Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1-…
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1-…
Artificial Synapse Based on a 2D-SnO2 Memtransistor with Dynamically Tunable Analog Switching for Neuromorphic Computing
A new type of two-dimensional (2D) SnO 2 semiconductor-based gate-tunable memristor,
that is, a memtransistor, an integrated device of a memristor and a transistor, was …
that is, a memtransistor, an integrated device of a memristor and a transistor, was …
Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome
AL Edwinson, L Yang, S Peters, N Hanning… - Nature …, 2022 - nature.com
Intestinal proteases mediate digestion and immune signalling, while increased gut proteolytic
activity disrupts the intestinal barrier and generates visceral hypersensitivity, which is …
activity disrupts the intestinal barrier and generates visceral hypersensitivity, which is …
A fully integrated 16-channel closed-loop neural-prosthetic CMOS SoC with wireless power and bidirectional data telemetry for real-time efficient human epileptic …
CH Cheng, PY Tsai, TY Yang… - IEEE Journal of Solid …, 2018 - ieeexplore.ieee.org
A 16-channel closed-loop neuromodulation system-on-chip (SoC) for human epileptic
seizure control is proposed and designed. In the proposed SoC, a 16-channel neural-signal …
seizure control is proposed and designed. In the proposed SoC, a 16-channel neural-signal …
Three-dimensional molybdenum diselenide helical nanorod arrays for high-performance aluminum-ion batteries
The rechargeable aluminum-ion battery (AIB) is a promising candidate for next-generation
high-performance batteries, but its cathode materials require more development to improve …
high-performance batteries, but its cathode materials require more development to improve …
Antisymmetric Magnetoresistance in a van der Waals Antiferromagnetic/Ferromagnetic Layered MnPS3/Fe3GeTe2 Stacking Heterostructure
The presence of two-dimensional (2D) layer-stacking heterostructures that can efficiently tune
the interface properties by stacking desirable materials provides a platform to investigate …
the interface properties by stacking desirable materials provides a platform to investigate …
Design of Core–Shell Quantum Dots–3D WS2 Nanowall Hybrid Nanostructures with High-Performance Bifunctional Sensing Applications
Transition metal dichalcogenides (TMDCs) have recently attracted a tremendous amount of
attention owing to their superior optical and electrical properties as well as the interesting …
attention owing to their superior optical and electrical properties as well as the interesting …
Irradiation-induced swelling and hardening in HfNbTaTiZr refractory high-entropy alloy
The lattice distortion and diffusion kinetics of refractory high-entropy alloys (RHEAs), which
may be endowed with superior radiation tolerance, render RHEAs candidate materials for …
may be endowed with superior radiation tolerance, render RHEAs candidate materials for …
Intercalation of zinc monochloride cations by deep eutectic solvents for high-performance rechargeable non-aqueous zinc ion batteries
Zinc ion batteries have been extensively studied with an aqueous electrolyte system. However,
the batteries suffer from a limited potential window, gas evolution, cathode dissolution, …
the batteries suffer from a limited potential window, gas evolution, cathode dissolution, …